Head-to-head · Cost-Efficiency Index
Aspire Health vs 1st Optimal
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Aspire Health
Cost-first shoppers who want nebraska telehealth: compounded + brand GLP-1s with labs included.
Visit Aspire Health1st Optimal
Patients who want a named founding physician and a broader functional-medicine/hormone workup alongside GLP-1s.
Visit 1st OptimalThe verdict
Aspire Health takes it, leading the Cost-Efficiency Index 42 to 41. Aspire Health is a Nebraska-based telehealth practice offering both compounded semaglutide/tirzepatide (formulated with B6) and brand-name Wegovy and Zepbound, prescribed by a named PA/NP clinical team. 1st Optimal still earns a C — Patients who want a named founding physician and a broader functional-medicine/hormone workup alongside GLP-1s.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Aspire Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Aspire Health | 1st Optimal |
|---|---|---|
| Cost-Efficiency Index | 42/100 | 41/100 |
| Semaglutide / mo | Not disclosed | Not disclosed |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | — | — |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | Yes |
| Brand-name access | Yes | Compounded only |
| Rank here | #511 | #518 |
Aspire Health
42/100Where the value is
- Both compounded and brand-name options (Wegovy + Zepbound) — rare among GLP-1 telehealth providers
- Lab orders with interpretation included in LoseIt membership — not billed separately
- Named clinical team: founded by Jenni Haan, MPAS, PA-C (18+ years experience) with four additional credentialed providers
The tradeoffs
- Membership fee ($75/month) stacks on top of separately billed medication — total spend $205–$524/month depending on dose
- No LegitScript certification or independent third-party accreditation disclosed
1st Optimal
41/100Where the value is
- Named founder and clinical lead: Dr. Amber Miller, a functional medicine physician
- LegitScript verification badge displayed
- No credit card required to start the intake quiz
The tradeoffs
- No GLP-1 pricing published anywhere on the public site
- No compounding pharmacy partner named
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.