Head-to-head · Cost-Efficiency Index
Sesame Care vs Center for Medical Weight Loss (CMWL)
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Sesame Care
People who specifically want FDA-approved brand-name medication (including the Wegovy pill or oral Rybelsus) from an established, verified marketplace and will budget for a two-part cost.
Visit Sesame CareCenter for Medical Weight Loss (CMWL)
Cost-first shoppers who want budget-conscious patients wanting flat any-dose compounded glp-1 from an established program.
Visit Center for Medical Weight Loss (CMWL)The verdict
Sesame Care takes it, leading the Cost-Efficiency Index 86 to 63. The widest real brand-name GLP-1 access on the board — a LegitScript- and BBB-recognized national marketplace running since 2018 that dispenses FDA-approved Wegovy, Zepbound, Ozempic, Mounjaro and Rybelsus, not compounded copies. Center for Medical Weight Loss (CMWL) still earns a C — Cost-first shoppers who want budget-conscious patients wanting flat any-dose compounded glp-1 from an established program.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the board). See how it stacks up: CoreAge Rx vs Sesame Care.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Sesame Care | Center for Medical Weight Loss (CMWL) |
|---|---|---|
| Cost-Efficiency Index | 86/100 | 63/100 |
| Semaglutide / mo | $149/mo (brand) | $149/mo (all doses, compounded) |
| Tirzepatide / mo | Brand (Zepbound) | $239/mo (all doses, compounded) |
| Semaglutide / yr (modeled) | — | $1,788 |
| Tirzepatide / yr (modeled) | — | $2,868 |
| Coverage | Nationwide | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Yes | Compounded only |
| Rank on the board | #6 | #184 |
Sesame Care
86/100Where the value is
- Widest brand-name formulary we list — Wegovy pen and pill, Zepbound, Ozempic, Mounjaro and oral Rybelsus, all FDA-approved rather than compounded
- Established national marketplace operating since 2018, with LegitScript certification and BBB recognition
- Wegovy pill starts around $149/mo, and oral routes are available for the needle-averse
The tradeoffs
- Two-part cost — the medication price is separate from a platform subscription, so the all-in monthly runs above the $149 headline
- A generalist telehealth marketplace, not a dedicated GLP-1 program
Center for Medical Weight Loss (CMWL)
63/100Where the value is
- Very competitive flat any-dose pricing (semaglutide from 116 dollars per month, tirzepatide from 159 dollars per month)
- Established Center for Medical Weight Loss brand with physician supervision and clinical support
- Fast 24-hour approvals and free three to five day shipping
The tradeoffs
- Some states are ineligible and the eligible-state list is not published
- Compounding pharmacy is not named publicly
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.