Head-to-head · Cost-Efficiency Index
PlushCare vs Rejuve Meds
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
PlushCare
Patients who want a real board-certified physician managing GLP-1s alongside general primary care, and are prepared to navigate insurance or a manufacturer cash-pay program rather than a single flat price.
Visit PlushCareRejuve Meds
Patients comfortable prepaying or financing a full 12-month commitment upfront in exchange for the lowest headline rate.
Visit Rejuve MedsThe verdict
PlushCare and Rejuve Meds tie on the Cost-Efficiency Index at 65/100, so neither wins outright on the numbers. For most shoppers we'd start with PlushCare (ranked #166, a hair above #167) — Patients who want a real board-certified physician managing GLP-1s alongside general primary care, and are prepared to navigate insurance or a manufacturer cash-pay program rather than a single flat price. But Rejuve Meds is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs PlushCare.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | PlushCare | Rejuve Meds |
|---|---|---|
| Cost-Efficiency Index | 65/100 | 65/100 |
| Semaglutide / mo | $199/mo (0.25 mg dose, plus a separate fee, brand-name) | $85/mo (compounded oral) |
| Tirzepatide / mo | $399/mo (5 mg dose, plus a separate fee, compounded) | $85/mo (12-month plan, compounded oral) |
| Semaglutide / yr (modeled) | $2,388 | $1,020 |
| Tirzepatide / yr (modeled) | $4,788 | $1,020 |
| Coverage | All 50 states | Coverage not published |
| Oral / sublingual | No | Yes |
| Brand-name access | Yes | Compounded only |
| Rank here | #166 | #167 |
PlushCare
65/100Where the value is
- Board-certified physicians (not NP-only) available in all 50 states for general virtual primary care
- Publishes an unusually granular compounded-tirzepatide dose ladder ($399/$599/$749 by vial count) instead of a vague single 'starting at' figure
- Brand Wegovy via NovoCare's manufacturer program can beat most compounded prices ($199-399/mo) when the promotion is genuinely still active
The tradeoffs
- Compounded tirzepatide and semaglutide are each only available in about 39 states plus DC, narrower than PlushCare's general 50-state telehealth business
- A $19.99/mo membership and, for uninsured patients, a $129 visit fee sit on top of every medication price and are easy to miss from the headline drug price alone
Rejuve Meds
65/100Where the value is
- Offers both injectable and dissolvable oral tablet formats for semaglutide and tirzepatide
- No insurance required, free shipping
- Claims a 14.9% average weight loss within a year based on GLP-1 use
The tradeoffs
- Headline '$85' price is a 12-month-prepay-equivalent rate, not a real monthly price -- the true month-to-month cost is undisclosed
- No medical director named anywhere on the site
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.