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Head-to-head · Cost-Efficiency Index

Ondra Health vs Vital Harmony Rx

Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.

Better valueGrade A− · #2

Ondra Health

Value shoppers who want one of the lowest disclosed prices on both molecules without giving up nationwide access or pharmacy verification.

Visit Ondra Health
VS
Grade C · #489

Vital Harmony Rx

Cost-first shoppers who want legitScript-verified compounded GLP-1 with semaglutide and tirzepatide options.

Visit Vital Harmony Rx

The verdict

Winner · Ondra HealthGrade A− vs C

Ondra Health takes it, leading the Cost-Efficiency Index 90 to 39. A rare combination — near-rock-bottom pricing on both molecules, all-50 access, brand-name availability, and a LegitScript-verified pharmacy behind it. Vital Harmony Rx still earns a CCost-first shoppers who want legitScript-verified compounded GLP-1 with semaglutide and tirzepatide options.

Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the board). See how it stacks up: CoreAge Rx vs Ondra Health.

Factor by factor

Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.

Normalized Cost/Month

94
45

Price Transparency

88
20

Nationwide Access

96
24

Formulation Options

86
40

Clinical Oversight

88
64

Contract Flexibility

88
55

Pricing, coverage & formulary

The disclosed facts behind the scores. Lower price wins its row (teal).

SpecOndra HealthVital Harmony Rx
Cost-Efficiency Index90/10039/100
Semaglutide / mo$93/moNot disclosed
Tirzepatide / mo$166/moNot disclosed
Semaglutide / yr (modeled)$1,116
Tirzepatide / yr (modeled)$1,992
CoverageAll 50 statesCoverage not published
Oral / sublingualNoNo
Brand-name accessYesCompounded only
Rank on the board#2#489

Ondra Health

90/100

Where the value is

  • Among the lowest disclosed prices on the board — $93 semaglutide and $166 tirzepatide
  • Available in all 50 states with both molecules published for clean cost modeling
  • LegitScript-certified, and offers FDA-approved brand-name access alongside compounded

The tradeoffs

  • A newer, lower-profile operator without CoreAge's long flat-price track record
  • No oral/sublingual route
Visit Ondra Health

Full Ondra Health review →

Vital Harmony Rx

39/100

Where the value is

  • Verified LegitScript certification (ID 49230211) — a trust signal many compounded-GLP-1 DTC brands lack
  • Explicit compounded-medication + 'not a pharmacy/manufacturer' disclosure on-site
  • Both a semaglutide (GLP-1+B12) and a tirzepatide (GLP-1/GIP+B12) option

The tradeoffs

  • NO pricing published anywhere on the site — a major gap for a cost-comparison directory; buyers cannot evaluate value without contacting the company
  • No specific state list (only 'entire country' claimed)
Visit Vital Harmony Rx

Full Vital Harmony Rx review →

Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.

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