Head-to-head · Cost-Efficiency Index
NativeMed vs Blue Sky MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
NativeMed
Cost-first shoppers who want a flat monthly rate regardless of dose, without a separate membership fee.
Visit NativeMedBlue Sky MD
Cost-first shoppers who want north Carolina residents who want an established, physician-led, LegitScript-certified in-person clinic.
Visit Blue Sky MDThe verdict
NativeMed and Blue Sky MD tie on the Cost-Efficiency Index at 63/100, so neither wins outright on the numbers. For most shoppers we'd start with NativeMed (ranked #187, a hair above #188) — Cost-first shoppers who want a flat monthly rate regardless of dose, without a separate membership fee. But Blue Sky MD is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs NativeMed.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | NativeMed | Blue Sky MD |
|---|---|---|
| Cost-Efficiency Index | 63/100 | 63/100 |
| Semaglutide / mo | $149/mo (all doses, 3-month plan, compounded) | $160/mo (starting dose, compounded) |
| Tirzepatide / mo | $183/mo (all doses, 3-month plan, compounded) | $240/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $1,788 | $1,920 |
| Tirzepatide / yr (modeled) | $2,196 | $2,880 |
| Coverage | Coverage not published | 1 state |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #187 | #188 |
NativeMed
63/100Where the value is
- Flat 'same price any dose' pricing removes the dose-tier price-creep common at other compounded GLP-1 sites
- No stated membership/platform fee stacked on top of the medication price
- Free 48-hour shipping advertised on the homepage
The tradeoffs
- The site's own '3-month starter' pricing table implies the real first-month charge ($179-$259) runs higher than the advertised $149-$183/mo headline rate
- No published list of which U.S. states NativeMed actually serves — a buyer can't confirm eligibility before starting the intake
Regulatory note: the FDA issued a warning letter to NativeMed LLC dba NativeMed in June 2026. We still list and link to NativeMed; you should know the letter is on the public record before you decide.
Blue Sky MD
63/100Where the value is
- LegitScript-certified with a named, pictured Medical Director (Dr. David LaMond) and a practice history dating to 2008
- Weekly pricing ($40 semaglutide / $60 tirzepatide) is well below brand-name cost and comparable to many compounded telehealth competitors
- 7 physical clinic locations across North Carolina (Charlotte, Asheville, Hendersonville, Greensboro, Clemmons, South Charlotte, Mooresville) for patients who want in-person care
The tradeoffs
- The published $40/$60 per-week price is explicitly labeled 'in-office' on the GLP-1 page, and that specific page never mentions telehealth at all — whether the rate applies to out-of-state or telehealth-only patients is unconfirmed
- Geographic footprint is North Carolina only; no state-by-state telehealth coverage list is published
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.