Head-to-head · Cost-Efficiency Index
NewSelf vs Piper
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
NewSelf
Budget shoppers who want a verified all-50 program and one of the lowest disclosed tirzepatide prices in the value tier.
Visit NewSelfPiper
Nationwide shoppers who want both molecules disclosed at fair prices and will do their own diligence on the pharmacy.
Visit PiperThe verdict
NewSelf takes it, leading the Cost-Efficiency Index 87 to 82. $100 semaglutide and $144 tirzepatide, nationwide and LegitScript-verified — near-identical value to the cheapest verified names, with the tirzepatide price a hair lower than most. Piper still earns a B− — Nationwide shoppers who want both molecules disclosed at fair prices and will do their own diligence on the pharmacy.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the board). See how it stacks up: CoreAge Rx vs NewSelf.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | NewSelf | Piper |
|---|---|---|
| Cost-Efficiency Index | 87/100 | 82/100 |
| Semaglutide / mo | $100/mo | $135/mo |
| Tirzepatide / mo | $144/mo | $199/mo |
| Semaglutide / yr (modeled) | $1,200 | $1,620 |
| Tirzepatide / yr (modeled) | $1,728 | $2,388 |
| Coverage | All 50 states | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank on the board | #6 | #22 |
NewSelf
87/100Where the value is
- $100 semaglutide / $144 tirzepatide — one of the cheapest verified combined prices on the board
- Nationwide all-50 coverage with both molecules published up front
- LegitScript-certified pharmacy behind the low price
The tradeoffs
- Compounded only — no brand-name or oral option
- Newer consumer brand with a thin public track record
Piper
82/100Where the value is
- Both molecules disclosed — $135 semaglutide / $199 tirzepatide — for clean cost modeling
- Nationwide all-50 access with predictable flat pricing
- Straightforward to model for a full year
The tradeoffs
- Not LegitScript-certified, so pharmacy oversight is harder to verify
- Compounded only — no brand-name or oral route
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.